Symbol
Name
ID

Rb1
RB transcriptional corepressor 1
MGI:97874

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Pinealoma
Disease(s) Associated with RB1	Pinealoma
retinoblastoma

Mouse Phenotypes

nervous system phenotype

increased neuron apoptosis

abnormal neuron differentiation

abnormal neuronal precursor proliferation

abnormal pituitary intermediate lobe morphology

pituitary intermediate lobe hyperplasia

increased pituitary gland tumor incidence

increased pituitary adenohypophysis tumor incidence

increased pituitary adenoma incidence

increased pituitary melanotroph tumor incidence

abnormal cochlear hair cell morphology

increased cochlear hair cell number

increased cochlear inner hair cell number

increased cochlear outer hair cell number

abnormal cochlear outer hair cell morphology

cochlear outer hair cell degeneration

cochlear hair cell degeneration

abnormal vestibular hair cell morphology

increased vestibular hair cell number

abnormal vestibular hair cell stereociliary bundle morphology

vestibular hair cell degeneration

increased brain tumor incidence

abnormal brain morphology

abnormal cerebellum external granule cell layer morphology

thin external granule cell layer

abnormal brain interneuron morphology

increased brain weight

decreased brain size

increased brain size

enlarged fourth ventricle

abnormal fourth ventricle morphology

dilated fourth ventricle

abnormal third ventricle morphology

abnormal frontal lobe morphology

abnormal cerebellar cortex morphology

abnormal Purkinje cell morphology

ectopic Purkinje cell

abnormal cerebellar granule layer morphology

abnormal cerebellar granule cell morphology

thin cerebellar granule layer

abnormal cerebellum vermis morphology

astrocytosis

gliosis

decreased retina ganglion cell number

decreased retina photoreceptor cell number

decreased retina rod cell number

absent retina bipolar cells

abnormal retina horizontal cell morphology

abnormal trigeminal ganglion morphology

abnormal dorsal root ganglion morphology

small dorsal root ganglion

neurodegeneration

Availability

Mouse Genotype

Rb1^tm1Brd/Rb1^tm1Brd

Rb1^tm1Dwg/Rb1^tm1Dwg

Rb1^tm1Mlh/Rb1^tm1Mlh

Rb1^tm1Tyj/Rb1^tm1Tyj

Rb1^tm1Tyj/Rb1^tm1Tyj
Tg(Rb1)1Blg/0

Rb1^tm2.1Fad/Rb1^tm2.1Fad

Rb1^tm2Mlh/Rb1^tm2Mlh

Rb1^tm1Brd/Rb1⁺

Rb1^tm1Mlh/Rb1⁺

Rb1^tm1Tyj/Rb1⁺

Rb1^tm1Tyj/Rb1^tm2Tyj

Rb1^tm2Mlh/Rb1⁺

Rb1^tm1Brn/Rb1^tm1Brn
Tg(Pomc-FLP)1aBrn/0 (conditional)

Rb1^tm1Brn/Rb1^tm1Brn
X/Tg(Pomc-FLP)1bBrn (conditional)

Rb1^tm2Brn/Rb1^tm2Brn
Tg(Rbp3-cre)1Brn/0 (conditional)

Rb1^tm2Brn/Rb1^tm2Brn
Tg(Col1a1-cre)1Bek/0 (conditional)

Rb1^tm2Brn/Rb1^tm2Brn
Tg(Pou4f3-cre)1Devet/0 (conditional)

Rb1^tm2Brn/Rb1^tm2Brn
Tg(En2-cre)22Alj/0 (conditional)

Rb1^tm2Brn/Rb1^tm2Brn
Tg(Pcp2-cre)756Mro/0 (conditional)

Rb1^tm2Brn/Rb1^tm2Brn
Tg(Gfap-cre)2Brn/0 (conditional)

Rb1^tm3Tyj/Rb1^tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0 (conditional)

Rb1^tm3Tyj/Rb1^tm3Tyj
Tg(Nes-cre)1Atp/0 (conditional)

Rb1^tm1Brn/Rb1⁺
Tg(Pomc-FLP)1aBrn/0 (conditional)

Rb1^tm1Brn/Rb1⁺
X/Tg(Pomc-FLP)1bBrn (conditional)

Rb1^tm1Dwg/Rb1^tm2Brn
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (conditional)

Rb1^tm3Tyj/Rb1^tm3.1Tyj
Tg(Nes-cre)1Atp/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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